Unknown,Transcriptomics,Genomics,Proteomics

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Reverse myocardial remodeling by aortic bending debanding in mice


ABSTRACT: The objective of this study was to identify alterations in gene expression during reverse myocardial remodeling in a mouse model of reversible pressure overload. Mice were subjected to 4 weeks of aortic banding (AB) or sham procedure (sAB), banding and subsequent debanding (DB3), or sham procedure and subsequent debanding (sDB3), with saccrifice 3 days after debanding. Microarray screening was performed in 3 mice from each group. Sham was used as control, and we used an ANOVA model for each gene programmed in R-script to identify the effect of debanding.

ORGANISM(S): Mus musculus

SUBMITTER: Johannes Bjørnstad 

PROVIDER: E-GEOD-24454 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Collagen isoform shift during the early phase of reverse left ventricular remodelling after relief of pressure overload.

Bjørnstad Johannes Lagethon JL   Sjaastad Ivar I   Nygård Ståle S   Hasic Almira A   Ahmed Mohammad Shakil MS   Attramadal Håvard H   Finsen Alexandra Vanessa AV   Christensen Geir G   Tønnessen Theis T  

European heart journal 20100605 2


<h4>Aims</h4>Aortic stenosis induces pressure overload and myocardial remodelling with concentric hypertrophy and alterations in extracellular matrix (ECM). Aortic valve replacement leads to reverse remodelling, a process of which knowledge is scarce. The aims of the present study were to examine alterations in myocardial gene expression and subsequently identify molecular alterations important for the early phase of reverse remodelling.<h4>Methods and results</h4>After 4 weeks of ascending aort  ...[more]

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