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Unknown,Transcriptomics,Genomics,Proteomics

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Adult zebrafish: cornea vs dermis

ABSTRACT: Transcriptional profiling of adult zebrafish cornea against dermis as a reference. Three biological repeats with dye swap (6 chips of 1x22k for 6 data sets).

ORGANISM(S): Danio rerio

SUBMITTER: Masanari Takamiya

PROVIDER: E-GEOD-24593 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Molecular description of eye defects in the zebrafish Pax6b mutant, sunrise, reveals a Pax6b-dependent genetic network in the developing anterior chamber.

Takamiya Masanari M Weger Benjamin D BD Schindler Simone S Beil Tanja T Yang Lixin L Armant Olivier O Ferg Marco M Schlunck Günther G Reinhard Thomas T Dickmeis Thomas T Rastegar Sepand S Strähle Uwe U

PloS one 20150218 2

The cornea is a central component of the camera eye of vertebrates and even slight corneal disturbances severely affect vision. The transcription factor PAX6 is required for normal eye development, namely the proper separation of the lens from the developing cornea and the formation of the iris and anterior chamber. Human PAX6 mutations are associated with severe ocular disorders such as aniridia, Peters anomaly and chronic limbal stem cell insufficiency. To develop the zebrafish as a model for ...[more]

PMID: 25692557

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