Unknown,Transcriptomics,Genomics,Proteomics

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SAGE Profiles of Rat Lung Tissues


ABSTRACT: Thirty-two SD rats (male, 150 grams, 50days) were randomly divided into four groups: normal control group, asthma group, acupuncture-treated asthma group and acupuncture-treated normal group. The rat lungs were removed immediately after the rats were died. The rat lungs were conserved in liquid nitrogen. SAGE analyses were dependent on the classic protocol (Velculescu VE, et al, Serial Analysis of Gene Expression Detailed Protocol, version 1.0e, 2000) available at the SAGENET website. Keyword = Rat Keyword = Lung Keyword = Asthma Keyword = SAGE Keyword = Acupuncture Keywords: disease state analysis

ORGANISM(S): Rattus norvegicus

SUBMITTER: Yong Qing Yang 

PROVIDER: E-GEOD-2475 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Serial analysis of gene expression in a rat lung model of asthma.

Yin Lei-Miao LM   Jiang Gong-Hao GH   Wang Yu Y   Wang Yan Y   Liu Yan-Yan YY   Jin Wei-Rong WR   Zhang Zen Z   Xu Yu-Dong YD   Yang Yong-Qing YQ  

Respirology (Carlton, Vic.) 20081101 7


<h4>Background and objective</h4>The pathogenesis and molecular mechanism underlying asthma remain undetermined. The purpose of this study was to identify genes and pathways involved in the early airway response (EAR) phase of asthma by using serial analysis of gene expression (SAGE).<h4>Methods</h4>Two SAGE tag libraries of lung tissues derived from a rat model of asthma and controls were generated. Bioinformatic analyses were carried out using the Database for Annotation, Visualization and Int  ...[more]

Publication: 1/2

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