Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Noa Novershtern
PROVIDER: E-GEOD-24759 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Novershtern Noa N Subramanian Aravind A Lawton Lee N LN Mak Raymond H RH Haining W Nicholas WN McConkey Marie E ME Habib Naomi N Yosef Nir N Chang Cindy Y CY Shay Tal T Frampton Garrett M GM Drake Adam C B AC Leskov Ilya I Nilsson Bjorn B Preffer Fred F Dombkowski David D Evans John W JW Liefeld Ted T Smutko John S JS Chen Jianzhu J Friedman Nir N Young Richard A RA Golub Todd R TR Regev Aviv A Ebert Benjamin L BL
Cell 20110101 2
Though many individual transcription factors are known to regulate hematopoietic differentiation, major aspects of the global architecture of hematopoiesis remain unknown. Here, we profiled gene expression in 38 distinct purified populations of human hematopoietic cells and used probabilistic models of gene expression and analysis of cis-elements in gene promoters to decipher the general organization of their regulatory circuitry. We identified modules of highly coexpressed genes, some of which ...[more]