Dataset Information
RNAi profiling of human transcripts affected by RNAi to POLRMT
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Peter Chumakov
PROVIDER: E-GEOD-2478 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Transcription of mammalian messenger RNAs by a nuclear RNA polymerase of mitochondrial origin.
Nature 20050801 7051
Transcription of eukaryotic genes is performed by three nuclear RNA polymerases, of which RNA polymerase II is thought to be solely responsible for the synthesis of messenger RNAs. Here we show that transcription of some mRNAs in humans and rodents is mediated by a previously unknown single-polypeptide nuclear RNA polymerase (spRNAP-IV). spRNAP-IV is expressed from an alternative transcript of the mitochondrial RNA polymerase gene (POLRMT). The spRNAP-IV lacks 262 amino-terminal amino acids of m ...[more]
