Mouse heart tissue: wild-type vs. aMHC-Calcineurin transgenic (CnTg)
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Paula da Costa Martins
PROVIDER: E-GEOD-25006 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
MicroRNA-199b targets the nuclear kinase Dyrk1a in an auto-amplification loop promoting calcineurin/NFAT signalling.
da Costa Martins Paula A PA Salic Kanita K Gladka Monika M MM Armand Anne-Sophie AS Leptidis Stefanos S el Azzouzi Hamid H Hansen Arne A Coenen-de Roo Christina J CJ Bierhuizen Marti F MF van der Nagel Roel R van Kuik Joyce J de Weger Roel R de Bruin Alain A Condorelli Gianluigi G Arbones Maria L ML Eschenhagen Thomas T De Windt Leon J LJ
Nature cell biology 20101121 12
MicroRNAs (miRs) are a class of single-stranded, non-coding RNAs of about 22 nucleotides in length. Increasing evidence implicates miRs in myocardial disease processes. Here we show that miR-199b is a direct calcineurin/NFAT target gene that increases in expression in mouse and human heart failure, and targets the nuclear NFAT kinase dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a (Dyrk1a), constituting a pathogenic feed forward mechanism that affects calcineurin-responsive gen ...[more]
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