Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Lauro Sumoy
PROVIDER: E-GEOD-25077 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
The Biochemical journal 20120301 2
PFKFB (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) catalyses the synthesis and degradation of Fru-2,6-P2 (fructose-2,6-bisphosphate), a key modulator of glycolysis and gluconeogenesis. The PFKFB3 gene is extensively involved in cell proliferation owing to its key role in carbohydrate metabolism. In the present study we analyse its mechanism of regulation by progestins in breast cancer cells. We report that exposure of T47D cells to synthetic progestins (ORG2058 or norgestrel) leads to ...[more]