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Global hypomethylation identifies loci targeted for hypermethylation in head and neck cancer: HNSCC

ABSTRACT: Genome-wide DNA methylation profiling of head and neck squamous cell carcinomas (HNSCCs). The Illumina Infinium 27k Human DNA methylation BeadChip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs in fresh-frozen tumor tissues. Samples included 91 tumors from the oralpharynx and larynx, reflecting all stages of disease, 18 normal head and neck National Disease Research Interchange (NDRI) samples, and 213 normal control blood samples. Bisulphite-converted DNA from the 91 head and neck squamous cell carcinoma samples were hybridized to the Illumina Infinium 27k Human Methylation Beadchip v1.2.

ORGANISM(S): Homo sapiens

SUBMITTER: Graham Poage 

PROVIDER: E-GEOD-25089 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Global hypomethylation identifies Loci targeted for hypermethylation in head and neck cancer.

Poage Graham M GM   Houseman E Andres EA   Christensen Brock C BC   Butler Rondi A RA   Avissar-Whiting Michele M   McClean Michael D MD   Waterboer Tim T   Pawlita Michael M   Marsit Carmen J CJ   Kelsey Karl T KT  

Clinical cancer research : an official journal of the American Association for Cancer Research 20110419 11

<h4>Purpose</h4>The human epigenome is profoundly altered in cancers, with a characteristic loss of methylation in repetitive regions and concomitant accumulation of gene promoter methylation. The degree to which these processes are coordinated is unclear so we investigated both in head and neck squamous cell carcinomas.<h4>Experimental design</h4>Global methylation was measured using the luminometric methylation assay (LUMA) and pyrosequencing of LINE-1Hs and AluYb8 repetitive elements in a ser  ...[more]

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