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Transcription profiling of human lung adenocarcinoma and a carcinogen-induced mouse model

ABSTRACT: Lung tumors

ORGANISM(S): Mus musculus

DISEASE(S): lung adenocarcinoma

SUBMITTER: Robert Stearman

PROVIDER: E-GEOD-2514 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Analysis of orthologous gene expression between human pulmonary adenocarcinoma and a carcinogen-induced murine model.

Stearman Robert S RS Dwyer-Nield Lori L Zerbe Laura L Blaine Stacy A SA Chan Zeng Z Bunn Paul A PA Johnson Gary L GL Hirsch Fred R FR Merrick Daniel T DT Franklin Wilbur A WA Baron Anna E AE Keith Robert L RL Nemenoff Raphael A RA Malkinson Alvin M AM Geraci Mark W MW

The American journal of pathology 20051201 6

Human adenocarcinoma (AC) is the most frequently diagnosed human lung cancer, and its absolute incidence is increasing dramatically. Compared to human lung AC, the A/J mouse-urethane model exhibits similar histological appearance and molecular changes. We examined the gene expression profiles of human and murine lung tissues (normal or AC) and compared the two species' datasets after aligning approximately 7500 orthologous genes. A list of 409 gene classifiers (P value <0.0001), common to both s ...[more]

PMID: 16314486

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Transcription profiling of human lung adenocarcinoma and a carcinogen-induced mouse model

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