Unknown,Transcriptomics,Genomics,Proteomics

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Genome-wide analysis of the affect of neutrophil-derived microparticles on HUVECs

ABSTRACT: Analysis of the role of neutrophil-derived microparticles (MP) on gene expression modulation on HUVECs. This study shows that MP can influence gene expression on target cells, demonstrating that these MP are functional entities. Total RNA obtained from HUVECs treated with two different subsets of MP: suspension MP or Adherent MP and vehicle control.

ORGANISM(S): Homo sapiens

SUBMITTER: Trinidad Montero 

PROVIDER: E-GEOD-25154 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Heterogeneity in neutrophil microparticles reveals distinct proteome and functional properties.

Dalli Jesmond J   Montero-Melendez Trinidad T   Norling Lucy V LV   Yin Xiaoke X   Hinds Charles C   Haskard Dorian D   Mayr Manuel M   Perretti Mauro M  

Molecular & cellular proteomics : MCP 20130508 8

Altered plasma neutrophil microparticle levels have recently been implicated in a number of vascular and inflammatory diseases, yet our understanding of their actions is very limited. Herein, we investigate the proteome of neutrophil microparticles in order to shed light on their biological actions. Stimulation of human neutrophils, either in suspension or adherent to an endothelial monolayer, led to the production of microparticles containing >400 distinct proteins with only 223 being shared by  ...[more]

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