Gene expression profiling of NOD mice and related congenic mice
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Zheng Liu
PROVIDER: E-GEOD-2524 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Deregulated stress system in non-obese diabetic lymphocyte.
Genes and immunity 20060511 5
Lymphopenia-induced homeostatic expansion in non-obese diabetic (NOD) mice may lead to autoimmunity. We demonstrated that NOD lymphocytes are more susceptible to apoptosis than those of non-diabetic C57BL/6 or NOD.H2(h4) mice in vivo and in vitro, which may be an underlying mechanism causing lymphopenia in NOD mice. Gene expression profiling identified a set of genes that are differentially expressed between NOD and B6 mice. Identity of these genes suggested that NOD T cells have a deregulated s ...[more]
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