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Molecular Cytogenetic Analysis of a Gliosarcoma with Osseous Metaplasia

ABSTRACT: Gliosarcoma, a rare glioblastoma variant, is composed of a glial and a mesenchymal component. Though the mesenchymal portion most commonly resembles a fibrosarcoma, other differentiation patterns have been observed. We present the first genomic characterisation (karyotyping followed by FISH and array-CGH analysis) of a gliosarcoma with osseous metaplasia. In addition to chromosomal changes often found in gliomas (+7,-10,-13, and -22), the tumour cells also harboured a hitherto unknown 3q21;21q21~22-translocation. As translocations are very rare in high-grade astrocytic tumours and have not formerly been seen in gliosarcomas, it is possible that the t(3;21) may be characteristic of gliosarcoma with osseous metaplasia. Tumour sample analysed with control DNA (supplied by Agilent)

ORGANISM(S): Homo sapiens

SUBMITTER: Hanne-Sofie Dahlback

PROVIDER: E-GEOD-25411 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Molecular cytogenetic analysis of a gliosarcoma with osseous metaplasia.

Dahlback H S S HS Gorunova L L Micci F F Scheie D D Brandal P P Meling T R TR Heim S S

Cytogenetic and genome research 20110505 2

Gliosarcoma, a rare glioblastoma variant, is composed of a glial and a mesenchymal component. Though the mesenchymal portion most commonly resembles a fibrosarcoma, other differentiation patterns have been observed. We present the first genomic characterisation (karyotyping followed by FISH and array comparative genomic hybridisation analysis) of a gliosarcoma with osseous metaplasia. In addition to chromosomal changes often found in gliomas (+7, -10, -13, and -22), the tumour cells also harbour ...[more]

PMID: 21555877

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| PRJNA134155 | ENA

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