High-resolution genome-wide in vivo footprinting of diverse transcription factors in human cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Terry Furey
PROVIDER: E-GEOD-25442 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
High-resolution genome-wide in vivo footprinting of diverse transcription factors in human cells.
Boyle Alan P AP Song Lingyun L Lee Bum-Kyu BK London Darin D Keefe Damian D Birney Ewan E Iyer Vishwanath R VR Crawford Gregory E GE Furey Terrence S TS
Genome research 20101124 3
Regulation of gene transcription in diverse cell types is determined largely by varied sets of cis-elements where transcription factors bind. Here we demonstrate that data from a single high-throughput DNase I hypersensitivity assay can delineate hundreds of thousands of base-pair resolution in vivo footprints in human cells that precisely mark individual transcription factor-DNA interactions. These annotations provide a unique resource for the investigation of cis-regulatory elements. We find t ...[more]
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