Ontology highlight
ABSTRACT:
ORGANISM(S): Arabidopsis thaliana
SUBMITTER: Falong Lu
PROVIDER: E-GEOD-25446 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Lu Falong F Cui Xia X Zhang Shuaibin S Jenuwein Thomas T Cao Xiaofeng X
Nature genetics 20110605 7
Polycomb group (PcG)-mediated histone H3 lysine 27 trimethylation (H3K27me3) has a key role in gene repression and developmental regulation. There is evidence that H3K27me3 is actively removed in plants, but it is not known how this occurs. Here we show that RELATIVE OF EARLY FLOWERING 6 (REF6), also known as Jumonji domain-containing protein 12 (JMJ12), specifically demethylates H3K27me3 and H3K27me2, whereas its metazoan counterparts, the KDM4 proteins, are H3K9 and H3K36 demethylases. Plants ...[more]