Unknown,Transcriptomics,Genomics,Proteomics

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A mouse model of deregulation of the malt1 oncogene recapitulates the pathogenesis of human malt lymphoma

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE25636: A mouse model of deregulation of the malt1 oncogene recapitulates the pathogenesis of human malt lymphoma [MouseSca1 dataset] GSE25637: A mouse model of deregulation of the malt1 oncogene recapitulates the pathogenesis of human malt lymphoma [Spleen dataset] GSE25638: A mouse model of deregulation of the malt1 oncogene recapitulates the pathogenesis of human malt lymphoma [MALT dataset] Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Victor Segura 

PROVIDER: E-GEOD-25639 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Expression of MALT1 oncogene in hematopoietic stem/progenitor cells recapitulates the pathogenesis of human lymphoma in mice.

Vicente-Dueñas Carolina C   Fontán Lorena L   Gonzalez-Herrero Ines I   Romero-Camarero Isabel I   Segura Victor V   Aznar M Angela MA   Alonso-Escudero Esther E   Campos-Sanchez Elena E   Ruiz-Roca Lucía L   Barajas-Diego Marcos M   Sagardoy Ainara A   Martinez-Ferrandis Jose I JI   Abollo-Jimenez Fernando F   Bertolo Cristina C   Peñuelas Ivan I   Garcia-Criado Francisco J FJ   García-Cenador María B MB   Tousseyn Thomas T   Agirre Xabier X   Prosper Felipe F   Garcia-Bragado Federico F   McPhail Ellen D ED   Lossos Izidore S IS   Du Ming-Qing MQ   Flores Teresa T   Hernandez-Rivas Jesus M JM   Gonzalez Marcos M   Salar Antonio A   Bellosillo Beatriz B   Conde Eulogio E   Siebert Reiner R   Sagaert Xavier X   Cobaleda Cesar C   Sanchez-Garcia Isidro I   Martinez-Climent Jose A JA  

Proceedings of the National Academy of Sciences of the United States of America 20120611 26

Chromosomal translocations involving the MALT1 gene are hallmarks of mucosa-associated lymphoid tissue (MALT) lymphoma. To date, targeting these translocations to mouse B cells has failed to reproduce human disease. Here, we induced MALT1 expression in mouse Sca1(+)Lin(-) hematopoietic stem/progenitor cells, which showed NF-κB activation and early lymphoid priming, being selectively skewed toward B-cell differentiation. These cells accumulated in extranodal tissues and gave rise to clonal tumors  ...[more]

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