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Multiorgan effects of IUGR caused by maternal protein depletion in rats (Placenta, Kidney, Heart, Lung, Liver)

ABSTRACT: All genome expression changes investigated on pools of growth restricted rats (at term) compared to control rats. The protocol of growth restriction (length, duration) has been extensively described in Buffat et al (Journal of Pathology 2007a and Endocrinology, 2007b) Ten hybridizations, two technical replicates, were carried out using RNAs prepared from pooled organs from 4 to 6 pups.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Daniel Vaiman

PROVIDER: E-GEOD-25764 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The intensity of IUGR-induced transcriptome deregulations is inversely correlated with the onset of organ function in a rat model.

Vaiman Daniel D Gascoin-Lachambre Géraldine G Boubred Farid F Mondon Françoise F Feuerstein Jean-Marc JM Ligi Isabelle I Grandvuillemin Isabelle I Barbaux Sandrine S Ghigo Eric E Achard Vincent V Simeoni Umberto U Buffat Christophe C

PloS one 20110622 6

A low-protein diet applied during pregnancy in the rat results in intrauterine growth restricted (IUGR) fetuses. In humans, IUGR is associated with increased perinatal morbidity, higher incidence of neuro-developmental defects and increased risk of adult metabolic anomalies, such as diabetes and cardiovascular disease. Development and function of many organs are affected by environmental conditions such as those inducing fetal and early postnatal growth restriction. This phenomenon, termed "feta ...[more]

PMID: 21731679

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