Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Hai Feng
PROVIDER: E-GEOD-25884 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
The Journal of clinical investigation 20110711 8
Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. It is more prevalent in men than women. Related to this, recent genetic studies have revealed a causal role for androgen receptor (AR) in hepatocarcinogenesis, but the underlying molecular mechanism remains unclear. Here, we used genome-wide location and functional analyses to identify a critical mediator of AR signaling - cell cycle-related kinase (CCRK) - that drives hepatocarcinogenesis via a signaling pathway dependent ...[more]