Expression data from Drosophila dLmo (EP1306 and BxJ) mutants
Ontology highlight
ABSTRACT:
ORGANISM(S): Drosophila melanogaster
SUBMITTER: Amy Lasek
PROVIDER: E-GEOD-25988 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
An evolutionary conserved role for anaplastic lymphoma kinase in behavioral responses to ethanol.
Lasek Amy W AW Lim Jana J Kliethermes Christopher L CL Berger Karen H KH Joslyn Geoff G Brush Gerry G Xue Liquan L Robertson Margaret M Moore Monica S MS Vranizan Karen K Morris Stephan W SW Schuckit Marc A MA White Raymond L RL Heberlein Ulrike U
PloS one 20110722 7
Anaplastic lymphoma kinase (Alk) is a gene expressed in the nervous system that encodes a receptor tyrosine kinase commonly known for its oncogenic function in various human cancers. We have determined that Alk is associated with altered behavioral responses to ethanol in the fruit fly Drosophila melanogaster, in mice, and in humans. Mutant flies containing transposon insertions in dAlk demonstrate increased resistance to the sedating effect of ethanol. Database analyses revealed that Alk expres ...[more]
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