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Copy number analysis of Hodgkin lymphoma cell lines KM-H2 and L-428

ABSTRACT: We identified copy number changes associated with fusion transcripts and breakpoints on chromosomes 15 and 16. Data integration with RNAseq data

ORGANISM(S): Homo sapiens

SUBMITTER: Christian Steidl

PROVIDER: E-GEOD-25989 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Hodgkin lymphoma

Project description:This SuperSeries is composed of the following subset Series: GSE25986: Gene expression profiling of cell lines derived from classical Hodgkin lymphoma GSE25987: Gene expression profiling of Hodgkin lymphoma cell line KMH2: Comparison of CIITA-BX648577 knockdown cultures with non-silencing controls GSE25989: Copy number analysis of Hodgkin lymphoma cell lines KM-H2 and L-428 Refer to individual Series *** This submission represents the microarray gene expression and microarray copy number components of the study

2010-12-11 | E-GEOD-25990 | biostudies-arrayexpress

Copy number analysis of Hodgkin lymphoma cell lines KM-H2 and L-428

Project description:We identified copy number changes associated with fusion transcripts and breakpoints on chromosomes 15 and 16.

2010-12-11 | GSE25989 | GEO

Melittin Increases Cisplatin Sensitivity and Kills KM-H2 and L-428 Hodgkin Lymphoma Cells.

Project description:Hodgkin lymphoma (HL) is neoplasia with high cure rates. However, not all patients can be cured with the current treatment. Chemo-resistance of tumor cells is one factor involved in treatment failure. In addition to its pore-forming activity on lipid bilayer membranes, the toxin melittin from bee venom is an inhibitor of several cancer-related signaling pathways. Moreover, melittin analogs have been shown to inhibit the activity of ATP binding cassette (ABC) transporters which are known to play important roles in the chemo-resistance of tumor cells. Therefore, we tested the toxicity of melittin for HL cell lines KM-H2 and L-428 and whether melittin can increase the chemo-sensitivity of cisplatin-resistant HL cells. We found high toxicity of melittin for KM-H2 and L-428 cells. In co-cultures with normal blood cells, melittin preferentially killed KM-H2 and L-428 cells. In addition, we observed increased cisplatin sensitivity of chemo-resistant L-428 cells after treatment with melittin. ABC transporter activity was not reduced after treatment with melittin. Our data suggest that melittin or melittin analogs might be promising agents for the future development of treatment strategies for HL patients with resistant disease.

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Expression data from EBER1-overexpressing Hodgkin lymphoma cell lines KM-H2 and L428

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Transcription profiling twenty eight growth restricted patients (including twenty two with Silver-Russel syndrome) and their parents

Project description:We studied twenty-eight growth restricted patients (twenty-two with Silver-Russell syndrome, OMIM#180860) and their parents with the Affymetrix 250K Sty SNP microarray. All patients were molecularly undefined, and thus the aim was to look for copy number alterations that might contribute to the growth restriction. Aberrations found in parents were used to reduce the list of interesting variations to de novo variants.

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Expression changes induced by PTPN1 knockdown in KM-H2 cells

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