Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Jeroen van de Peppel
PROVIDER: E-GEOD-26004 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Drabek Ksenija K van de Peppel Jeroen J Eijken Marco M van Leeuwen Johannes P T M JP
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20110901 9
Neuronal membrane glycoprotein gene (GPM6B) encodes a membrane glycoprotein that belongs to the proteolipid protein family. We identified GPM6B as a gene that is strongly upregulated during osteoblast differentiation. To investigate the role of GPM6B in the process of bone formation, we silenced GPM6B expression during osteogenic differentiation of human mesenchymal stem cells (hMSCs). GPM6B silencing in hMSCs resulted in reduced alkaline phosphate (ALP) activity along with reduced mineralizatio ...[more]