Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Transcription profiling of human primary breast tumors and MDA-MB-231 subpopulations


ABSTRACT: Subpopulations of MDA-MB-231 that exhibit different metastatic tropisms when injected into immuno-deficient mice. Also, a cohort of primary breast cancers surgically resected at the Memorial Sloan-Kettering Cancer Center (MSKCC).

ORGANISM(S): Homo sapiens

SUBMITTER: Agnes Viale 

PROVIDER: E-GEOD-2603 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications


By means of in vivo selection, transcriptomic analysis, functional verification and clinical validation, here we identify a set of genes that marks and mediates breast cancer metastasis to the lungs. Some of these genes serve dual functions, providing growth advantages both in the primary tumour and in the lung microenvironment. Others contribute to aggressive growth selectively in the lung. Many encode extracellular proteins and are of previously unknown relevance to cancer metastasis. ...[more]

Similar Datasets

2005-07-28 | GSE2603 | GEO
2017-10-31 | GSE93175 | GEO
2012-10-02 | GSE41258 | GEO
2008-10-26 | E-GEOD-10783 | biostudies-arrayexpress
2012-10-02 | E-GEOD-41258 | biostudies-arrayexpress
2008-06-12 | E-GEOD-3218 | biostudies-arrayexpress
2014-05-02 | GSE54077 | GEO
2009-12-18 | E-GEOD-14045 | biostudies-arrayexpress
2018-01-08 | GSE108838 | GEO
2021-09-23 | GSE184585 | GEO