Unknown,Transcriptomics,Genomics,Proteomics

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Expression data from cultured human lung tissue-derived fibroblasts and human vascular adventitial fibroblasts

ABSTRACT: In order to find the difference between human lung tissue-derived fibroblasts and human vascular adventitial fibroblasts for enhancing tumor formation ablity of human lung adenocarcinoma cell line A549, we found that human vascular adventitial fibroblasts enhance A549 tumor formation in vivo compared to human lung tissue-derived fibroblasts. To find the responsible genes for this phenomena, we used microarray analysis to find the expression difference between lung tissue-derived fibroblasts and vascular adventitial fibroblas Cultured human lung tissue-derived fibroblasts and human vascular adventitial fibroblasts were analyzed in replicates.

ORGANISM(S): Homo sapiens

SUBMITTER: Ayuko Hoshino 

PROVIDER: E-GEOD-26146 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Podoplanin-positive fibroblasts enhance lung adenocarcinoma tumor formation: podoplanin in fibroblast functions for tumor progression.

Hoshino Ayuko A   Ishii Genichiro G   Ito Takashi T   Aoyagi Kazuhiko K   Ohtaki Yoichi Y   Nagai Kanji K   Sasaki Hiroki H   Ochiai Atsushi A  

Cancer research 20110524 14

During the metastatic process, cancer cells interact with vascular adventitial fibroblasts (VAF), which are the main components of the outermost connective tissue layer of blood vessels. This activity suggests the presence of a specific tumor microenvironment in the perivascular area. The s.c. coinjection of human lung adenocarcinoma cell lines (A549, PC-14, and CRL-5807) and human VAF (hVAF) resulted in a high rate of tumor formation, compared with the coinjection of these cell lines and human  ...[more]

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