Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Emil Unanue
PROVIDER: E-GEOD-26147 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Calderon Boris B Carrero Javier A JA Miller Mark J MJ Unanue Emil R ER
Proceedings of the National Academy of Sciences of the United States of America 20110110 4
In an accompanying paper, we find specific localization of diabetogenic T cells only to islets of Langerhans bearing the specific antigen. Instrumental in the specific localization was the presence of intraislet dendritic cells bearing the β-cell-peptide-MHC complex. Here, we report that the entry of diabetogenic CD4 T cells very rapidly triggered inflammatory gene expression changes in islets and vessels by up-regulating chemokines and adhesion molecules. Vascular cell adhesion molecule-1 (VCAM ...[more]