Unknown,Transcriptomics,Genomics,Proteomics

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Late-stage embryonic gene expression in three cartilaginous fishes


ABSTRACT: Gene expression profiling of pooled late stage embryos from Leucoraja erinacea, Scyliorhinus canicula and Callorhinchus milii show that HOXC cluster genes are not expressed in the two elasmobranch fishes, L. erinacea and S. canicula. This finding supports the observations that these genes are not found in whole genome shotgun sequencing of L. erinacea or genomic clones from S. canicula. Profile gene expression in pooled late stage embryos from three species (L. erinacea, S. canicula and C. milii)

ORGANISM(S): Leucoraja erinacea

SUBMITTER: Benjamin King 

PROVIDER: E-GEOD-26235 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

A natural deletion of the HoxC cluster in elasmobranch fishes.

King Benjamin L BL   Gillis J Andrew JA   Carlisle Heather R HR   Dahn Randall D RD  

Science (New York, N.Y.) 20111201 6062


Hox proteins are a metazoan-specific family of transcription factors that are required for developmental patterning. The genomic arrangement of Hox genes into four paralogous clusters is a primitive feature of jawed vertebrates. By using high-throughput sequencing, we demonstrate the absence of all HoxC transcripts from embryos of the shark Scyliorhinus canicula and the skate Leucoraja erinacea and the absence of all HoxC genes and two HoxC-associated microRNAs from the genome of L. erinacea. Th  ...[more]

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