Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Ali Torkamani
PROVIDER: E-GEOD-26257 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Degner Stephanie C SC Verma-Gaur Jiyoti J Wong Timothy P TP Bossen Claudia C Iverson G Michael GM Torkamani Ali A Vettermann Christian C Lin Yin C YC Ju Zhongliang Z Schulz Danae D Murre Caroline S CS Birshtein Barbara K BK Schork Nicholas J NJ Schlissel Mark S MS Riblet Roy R Murre Cornelis C Feeney Ann J AJ
Proceedings of the National Academy of Sciences of the United States of America 20110523 23
Compaction and looping of the ~2.5-Mb Igh locus during V(D)J rearrangement is essential to allow all V(H) genes to be brought in proximity with D(H)-J(H) segments to create a diverse antibody repertoire, but the proteins directly responsible for this are unknown. Because CCCTC-binding factor (CTCF) has been demonstrated to be involved in long-range chromosomal interactions, we hypothesized that CTCF may promote the contraction of the Igh locus. ChIP sequencing was performed on pro-B cells, revea ...[more]