Unknown,Transcriptomics,Genomics,Proteomics

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The Adaptive Response of Endothelial Cells to Increased Shear Stress


ABSTRACT: In this study, we characterized the adaptive response of arterial endothelial cells to acute increases in shear stress magnitude in well-defined in vitro settings. Porcine endothelial cells were preconditioned by a basal level shear stress of 15 ± 15 dynes/cm2 at 1 Hz for 24 hours, and an acute increase in shear stress magnitude (30 ± 15 dynes/cm2) was then applied. The transcriptomics studies using microarray identified genes that were sensitive to the elevated shear magnitude. A significant number of the identified genes in our study are previously unknown as sensitive to shear stress. Porcine endothelial cells were preconditioned by a basal level shear stress of 15 ± 15 dynes/cm2 at 1 Hz for 24 hours, and an acute increase in shear stress magnitude (30 ± 15 dynes/cm2) was then applied. Gene expression at multiple time points was measured using microarray.

ORGANISM(S): Sus scrofa

SUBMITTER: Ji Zhang 

PROVIDER: E-GEOD-26505 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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