Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Salam Assi
PROVIDER: E-GEOD-26550 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Leddin Mathias M Perrod Chiara C Hoogenkamp Maarten M Ghani Saeed S Assi Salam S Heinz Sven S Wilson Nicola K NK Follows George G Schönheit Jörg J Vockentanz Lena L Mosammam Ali M AM Chen Wei W Tenen Daniel G DG Westhead David R DR Göttgens Berthold B Bonifer Constanze C Rosenbauer Frank F
Blood 20110114 10
The transcription factor PU.1 occupies a central role in controlling myeloid and early B-cell development, and its correct lineage-specific expression is critical for the differentiation choice of hematopoietic progenitors. However, little is known of how this tissue-specific pattern is established. We previously identified an upstream regulatory cis element whose targeted deletion in mice decreases PU.1 expression and causes leukemia. We show here that the upstream regulatory cis element alone ...[more]