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Gene expression profile of SYT-SSX2-expressing human bone marrow-derived mesenchymal stem cells

ABSTRACT: Synovial sarcoma is a rare malignancy characterized by the presence of a specific chromosomal translocation t(X;18) that results in the formation of a fusion protein SYT-SSX. Because it is believed that synovial sarcoma arises from mesenchymal stem or progenitor cells, we used human bone marrow-derived mesenchymal stem cells (MSCs) to determine the changes in gene expression caused by this oncogene in untransformed MSCs. In 2 independent experiments, human bone marrow-derived MSCs were infected with retrovirus carrying either control vector (pOZ) or SYT-SSX2 expression vector. Total cellular RNA was extracted 4 days post-infection and utilized for microarray analysis on Affymetrix arrays.

ORGANISM(S): Homo sapiens

SUBMITTER: Josiane Eid

PROVIDER: E-GEOD-26563 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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