HoxB4 in hematopoietic stem cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Takaho Endo
PROVIDER: E-GEOD-26653 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Genome-wide analysis of target genes regulated by HoxB4 in hematopoietic stem and progenitor cells developing from embryonic stem cells.
Oshima Motohiko M Endoh Mitsuhiro M Endo Takaho A TA Toyoda Tetsuro T Nakajima-Takagi Yaeko Y Sugiyama Fumihiro F Koseki Haruhiko H Kyba Michael M Iwama Atsushi A Osawa Mitsujiro M
Blood 20110222 15
Forced expression of the transcription factor HoxB4 has been shown to enhance the self-renewal capacity of mouse bone marrow hematopoietic stem cells (HSCs) and confer a long-term repopulating capacity to yolk sac and embryonic stem (ES) cell-derived hematopoietic precursors. The fact that ES cell-derived precursors do not repopulate bone marrow without HoxB4 underscores an important role for HoxB4 in the maturation of ES-derived hematopoietic precursors into long-term repopulating HSCs. However ...[more]
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