MiR148b is a major coordinator of breast cancer progression in a relapse-associated microRNA signature by targeting ITGA5, ROCK1, PIK3CA, NRAS and CSF1
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ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Gerolamo Lanfranchi
PROVIDER: E-GEOD-26666 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
miR148b is a major coordinator of breast cancer progression in a relapse-associated microRNA signature by targeting ITGA5, ROCK1, PIK3CA, NRAS, and CSF1.
Cimino Daniela D De Pittà Cristiano C Orso Francesca F Zampini Matteo M Casara Silvia S Penna Elisa E Quaglino Elena E Forni Marco M Damasco Christian C Pinatel Eva E Ponzone Riccardo R Romualdi Chiara C Brisken Cathrin C De Bortoli Michele M Biglia Nicoletta N Provero Paolo P Lanfranchi Gerolamo G Taverna Daniela D
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20121211 3
Breast cancer is often fatal during its metastatic dissemination. To unravel the role of microRNAs (miRs) during malignancy, we analyzed miR expression in 77 primary breast carcinomas and identified 16 relapse-associated miRs that correlate with survival and/or distinguish tumor subtypes in different datasets. Among them, miR-148b, down-regulated in aggressive breast tumors, was found to be a major coordinator of malignancy. In fact, it is able to oppose various steps of tumor progression when o ...[more]
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