Unknown,Transcriptomics,Genomics,Proteomics

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Genome-wide binding of Sd and Yki in imaginal discs


ABSTRACT: The transcription cofactor Yki drives growth and proliferation in part by controlling mitochondrial network formation. To determine if Yki and Sd are directly bound to DNA corresponding to mitochondrial genes, we used chromatin immunoprecipitation and whole genome tiling arrays (ChIP-chip) to identify regions bound by these factors in eye-antenna and wing imaginal discs. The supplementary .bed files contain all Yki or Sd binding sites (called at 5% FDR) in wing or eye-antenna imaginal discs, as well as shared Sd+Yki sites and associated target genes. Wing or eye-antenna imaginal discs ChIPped for Yki or Sd-GFP vs. input DNA from corresponding imaginal discs.

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Matthew Slattery 

PROVIDER: E-GEOD-26678 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Control of mitochondrial structure and function by the Yorkie/YAP oncogenic pathway.

Nagaraj Raghavendra R   Gururaja-Rao Shubha S   Jones Kevin T KT   Slattery Matthew M   Negre Nicolas N   Braas Daniel D   Christofk Heather H   White Kevin P KP   Mann Richard R   Banerjee Utpal U  

Genes & development 20120827 18


Mitochondrial structure and function are highly dynamic, but the potential roles for cell signaling pathways in influencing these properties are not fully understood. Reduced mitochondrial function has been shown to cause cell cycle arrest, and a direct role of signaling pathways in controlling mitochondrial function during development and disease is an active area of investigation. Here, we show that the conserved Yorkie/YAP signaling pathway implicated in the control of organ size also functio  ...[more]

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