Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Coordinated Chromatin Remodeling induced by Demethylation requires SRCAP mediated H2A.Z exchange


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Houtan Noushmehr 

PROVIDER: E-GEOD-26685 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Gene reactivation by 5-aza-2'-deoxycytidine-induced demethylation requires SRCAP-mediated H2A.Z insertion to establish nucleosome depleted regions.

Yang Xiaojing X   Noushmehr Houtan H   Han Han H   Andreu-Vieyra Claudia C   Liang Gangning G   Jones Peter A PA  

PLoS genetics 20120329 3


5-Aza-2'-deoxycytidine, approved by the FDA for the treatment of myelodysplastic syndrome (MDS), is incorporated into the DNA of dividing cells where it specifically inhibits DNA methylation by forming covalent complexes with the DNA methyltransferases (DNMTs). In an effort to study the correlations between DNA methylation, nucleosome remodeling, and gene reactivation, we investigate the integrated epigenetic events that worked coordinately to reprogram the methylated and closed promoters back t  ...[more]

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