Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Houtan Noushmehr
PROVIDER: E-GEOD-26685 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Yang Xiaojing X Noushmehr Houtan H Han Han H Andreu-Vieyra Claudia C Liang Gangning G Jones Peter A PA
PLoS genetics 20120329 3
5-Aza-2'-deoxycytidine, approved by the FDA for the treatment of myelodysplastic syndrome (MDS), is incorporated into the DNA of dividing cells where it specifically inhibits DNA methylation by forming covalent complexes with the DNA methyltransferases (DNMTs). In an effort to study the correlations between DNA methylation, nucleosome remodeling, and gene reactivation, we investigate the integrated epigenetic events that worked coordinately to reprogram the methylated and closed promoters back t ...[more]