Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptomic response of murine liver to severe injury and hemorrhagic shock


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE26695: Transcriptomic response of murine liver to severe injury and hemorrhagic shock: Affymetrix portion of dual platform GSE26696: Transcriptomic response of murine liver to severe injury and hemorrhagic shock: CodeLink portion of dual platform Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Joyeeta Dutta-Moscato 

PROVIDER: E-GEOD-26697 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Transcriptomic response of murine liver to severe injury and hemorrhagic shock: a dual-platform microarray analysis.

Edmonds Rebecca D RD   Vodovotz Yoram Y   Lagoa Claudio C   Dutta-Moscato Joyeeta J   Yang Yawching Y   Fink Mitchell P MP   Levy Ryan M RM   Prince Jose M JM   Kaczorowski David J DJ   Tseng George C GC   Billiar Timothy R TR  

Physiological genomics 20110809 20


Trauma-hemorrhagic shock (HS/T) is a complex process that elicits numerous molecular pathways. We hypothesized that a dual-platform microarray analysis of the liver, an organ that integrates immunology and metabolism, would reveal key pathways engaged following HS/T. C57BL/6 mice were divided into five groups (n = 4/group), anesthetized, and surgically treated to simulate a time course and trauma severity model: 1) nonmanipulated animals, 2) minor trauma, 3) 1.5 h of hemorrhagic shock and severe  ...[more]

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