Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression analysis of dendritic cells from normal or tumor sections of human prostates

ABSTRACT: Tumors cause the induction or repression of many genes associated with inflammation. To investigate the up and down regulation of genes associated with immune stimulation or immune tolerance RNA was isolated from dendritic cells from normal or tumor bearing prostate for microarray analysis. Using normal or tumorogenic sections of human prostates as determined by Pathology experts (UMD). Keywords: Comparative gene expression, prostate cancer, dendritic cells Prostatic dendritic cells were isolated from 5 patients for comparison of gene expression.

ORGANISM(S): Homo sapiens

SUBMITTER: Stephanie Watkins 

PROVIDER: E-GEOD-26747 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

FOXO3 programs tumor-associated DCs to become tolerogenic in human and murine prostate cancer.

Watkins Stephanie K SK   Zhu Ziqiang Z   Riboldi Elena E   Shafer-Weaver Kim A KA   Stagliano Katherine E R KE   Sklavos Martha M MM   Ambs Stefan S   Yagita Hideo H   Hurwitz Arthur A AA  

The Journal of clinical investigation 20110323 4

The limited success of cancer immunotherapy is often attributed to the loss of antigen-specific T cell function in situ. However, the mechanism for this loss of function is unknown. In this study, we describe a population of tumor-associated DCs (TADCs) in both human and mouse prostate cancer that tolerizes and induces suppressive activity in tumor-specific T cells. In tumors from human prostate cancer patients and transgenic adenocarcinoma of the mouse prostate (TRAMP) mice, TADCs expressed ele  ...[more]

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