Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Cliff Takemoto
PROVIDER: E-GEOD-26783 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Lee Youl-Nam YN Brandal Stephanie S Noel Pierre P Wentzel Erik E Mendell Joshua T JT McDevitt Michael A MA Kapur Reuben R Carter Melody M Metcalfe Dean D DD Takemoto Clifford M CM
Blood 20110127 13
Activating mutations in codon D816 of the tyrosine kinase receptor, KIT, are found in the majority of patients with systemic mastocytosis. We found that the transcription factor, microphthalmia-associated transcription factor (MITF), is highly expressed in bone marrow biopsies from 9 of 10 patients with systemic mastocytosis and activating c-KIT mutations. In primary and transformed mast cells, we show that KIT signaling markedly up-regulates MITF protein. We demonstrate that MITF is required fo ...[more]