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Transcription profiling of rat heart tissue samples from animals undergoing different exercise regimens

ABSTRACT: The interaction of genetics and environment play a major role in health and disease. Therefore, modeling experiments to investigate gene-environment interaction in a laboratory setting would provide the opportunity to gain mechanistic insight under controlled conditions. In laboratory research it is unclear if the gene-environment interaction of a sedentary lifestyle predisposes laboratory animals to hypokinetic diseases. Experiment Overall Design: We are seeking to compare gene expression and physiological markers of health and wellness in animals with: i. a sedentary lifestyle in a standard cage (CSS1-4); ii. access to twice-weekly physical activity in a large box outside a standard cage (CSA1-4); and iii. access to regular exercise in cages with running wheels (CSR1-4).

ORGANISM(S): Rattus norvegicus

SUBMITTER: Natalie Schweitzer

PROVIDER: E-GEOD-2690 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Access to exercise and its relation to cardiovascular health and gene expression in laboratory animals.

Schweitzer Natalie B NB Alessio Helaine M HM Hagerman Ann E AE Roy Sashwati S Sen Chandan K CK Nagy Szilvia S Byrnes Robyn N RN Philip Ben N BN Woodward Jane L JL Wiley Ronald L RL

Life sciences 20050901 18

The interaction between genes and environment can influence cardiovascular disease (CVD). This 16 month study investigated if genes associated with cardiovascular (CV) regulation were expressed differently in animals having: 1) no access to physical activity or exercise (SED), 2) access to hour-long, twice weekly activity (PA), and 3) access every-other-day to a running wheel (EX). Out of 31,000 genes, a CV subset comprising 44 genes was investigated. Ten genes from this subset were expressed di ...[more]

PMID: 16002099

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