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Clr4/Suv39 and RNA quality control factors cooperate to trigger RNAi and suppress antisense RNA

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Schizosaccharomyces pombe

SUBMITTER: Shiv Grewal

PROVIDER: E-GEOD-26999 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Clr4/Suv39 and RNA quality control factors cooperate to trigger RNAi and suppress antisense RNA.

Zhang Ke K Fischer Tamas T Porter Rebecca L RL Dhakshnamoorthy Jothy J Zofall Martin M Zhou Ming M Veenstra Timothy T Grewal Shiv I S SI

Science (New York, N.Y.) 20110301 6024

Pervasive transcription of eukaryotic genomes generates a plethora of noncoding RNAs. In fission yeast, the heterochromatin factor Clr4/Suv39 methyltransferase facilitates RNA interference (RNAi)-mediated processing of centromeric transcripts into small interfering RNAs (siRNAs). Clr4 also mediates degradation of antisense RNAs at euchromatic loci, but the underlying mechanism has remained elusive. We show that Clr4 and the RNAi effector RITS (RNA-induced transcriptional silencing) interact with ...[more]

PMID: 21436456

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