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Expression data from aged spermatogonial stem cells

ABSTRACT: In vitro and in vivo aging of mouse spermatogonial stem cells alters stem cell function based on quantitative spermatogonial stem cell transplantation analyses. We used microarrays to identify differential gene expression in vitro and in vivo aged spermatogonial stem cells to identify potential causes of observed phenotypic differences in aged spermatogonial stem cell function. Spermatogonial stem cells were isolated from young and serial-transplanted aged mouse donors and cultured for short and long periods. Spermatogonial stem cells were isolated from cultures and subjected to microarray analysis to identify differential gene expression.

ORGANISM(S): Mus musculus

SUBMITTER: Zhiyv Niu 

PROVIDER: E-GEOD-27043 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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In vivo and in vitro aging is detrimental to mouse spermatogonial stem cell function.

Schmidt Jonathan A JA   Abramowitz Lara K LK   Kubota Hiroshi H   Wu Xin X   Niu Zhiyv Z   Avarbock Mary R MR   Tobias John W JW   Bartolomei Marisa S MS   Brinster Ralph L RL  

Biology of reproduction 20101229 4

The development of techniques to maintain the spermatogonial stem cell (SSC) in vivo and in vitro for extended periods essentially allows for the indefinite continuation of an individual germline. Recent evidence indicates that the aging of male reproductive function is due to failure of the SSC niche. SSCs are routinely cultured for 6 mo, and no apparent effect of culture over this period has been observed. To determine the effects of SSC aging, we utilized an in vitro culture system, followed  ...[more]

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