Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

The comparison of gene expression profile in the amygdalae between the wild-type and neuropsin knock-out mice

ABSTRACT: Extracellular proteolysis contributes to fear-associated responses by facilitating neuronal plasticity at the neuron-matrix interface. A serine protease neuropsin is critical for stress-related plasticity in the amygdala by regulating the strength of EphB2/NMDA receptor interaction controlling the expression of fear-related genes and anxiety-like behavior. To look for downstream effects of neuropsin-mediated disassembly of the EphB2/NR1 complex we analyzed gene expression in the amygdalae of wild-type and neuropsin-/- mice. Wild-type control and neuropsin-/- mice were anaesthetised and perfused transcardially with ice cold PBS. The brains were removed and dissected using a vibrating microtome. Amygdalae were dissected from a coronal slice and were stored in RNAlater until processed. The amygdalae have been isolated from 15 brains of neuropsin-/- and 15 wild-type control animals. RNA pulled from 3 animals has been reverse transcribed and hybridized with GeneChip Mouse Exon 1.0 ST Affymetrix Array.

ORGANISM(S): Mus musculus

SUBMITTER: Marcin Piechota 

PROVIDER: E-GEOD-27088 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

A minority of individuals experiencing traumatic events develop anxiety disorders. The reason for the lack of correspondence between the prevalence of exposure to psychological trauma and the development of anxiety is unknown. Extracellular proteolysis contributes to fear-associated responses by facilitating neuronal plasticity at the neuron-matrix interface. Here we show in mice that the serine protease neuropsin is critical for stress-related plasticity in the amygdala by regulating the dynami  ...[more]

Similar Datasets

Transcriptomics The comparison of gene expression profile in the amygdalae between the wild-type and neuropsin knock-out mice
2011-05-13 | GSE27088 | GEO
Transcriptomics Expression and alternative splicing data from 1-month-old Rbfox1 KO brain
2011-05-16 | E-GEOD-28421 | biostudies-arrayexpress
Transcriptomics miRNA and consolidation of cued fear memory
2014-09-30 | E-GEOD-59072 | biostudies-arrayexpress
Transcriptomics Selection for contextual fear conditioning affects anxiety-like behaviors and gene expression (palme-affy-mouse-84746)
2006-01-13 | GSE4035 | GEO
Proteomics Hypothalamic Proteomics analysis of lipopolysaccharide (LPS)-induced depressed mice
2020-01-09 | PXD016040 | Pride
Transcriptomics Rapid selection response for contextual fear conditioning in a cross between C57BL/6J and A/J (palme-affy-mouse-198967)
2006-01-13 | GSE4034 | GEO
Transcriptomics Transcription profiling by array of mouse amygdala to detect transcripts regulated by psychological stress
2013-04-01 | E-MTAB-1519 | biostudies-arrayexpress
Transcriptomics EphB2 Receptor Promotes Dermal Fibrosis in Systemic Sclerosis
2024-04-10 | GSE253089 | GEO
Transcriptomics Transcriptional characterization of mPFCs
2019-08-20 | GSE134808 | GEO
Transcriptomics FoxO6 regulates memory consolidation and synaptic function.
2012-11-08 | E-GEOD-42097 | biostudies-arrayexpress