Unknown,Transcriptomics,Genomics,Proteomics

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GAP aflR- vs WT timecourse


ABSTRACT: The carcinogen aflatoxin is synthesized by a cluster of genes that are regulated by the transcriptional factor, AflR. Most, but not all of these genes, have a consensus binding site for AflR in their 5’ untranslated region. Because aflR resides within the biosynthetic cluster, is has been suggested that it regulates only genes within the cluster. The objective of this study was to identify those genes transcriptionally regulated by AflR and to determine if any of those genes reside outside the aflatoxin biosynthetic cluster. To address this objective, we employed a cDNA microarray of 5,002 genes from Aspergillus flavus to monitor the expression of genes in a wild type and an aflR deletion strain of A. parasiticus. Keywords = aspergillus Keywords = aflatoxin Keywords = regulation Keywords = secondary metabolism

ORGANISM(S): Aspergillus parasiticus

SUBMITTER: Jiujiang Yu 

PROVIDER: E-GEOD-2709 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The aflatoxin pathway regulator AflR induces gene transcription inside and outside of the aflatoxin biosynthetic cluster.

Price Michael S MS   Yu Jiujiang J   Nierman William C WC   Kim H Stanley HS   Pritchard Bethan B   Jacobus Carrie A CA   Bhatnagar Deepak D   Cleveland Thomas E TE   Payne Gary A GA  

FEMS microbiology letters 20060201 2


Aflatoxin contamination of food and feed is a major concern due to the carcinogenic properties of this mycotoxin. Previous studies using classical approaches have identified a cluster of genes responsible for aflatoxin production under the control of the pathway-specific transcriptional regulator aflR, but it is unknown whether aflR controls expression of other genes within the genome. Transcription profiling comparing wild type and DeltaaflR strains of Aspergillus parasiticus grown under condit  ...[more]

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