Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of rat parous and AMV mammary gland before and after MNU treatment


ABSTRACT: Early full-term pregnancy affords lifetime protection against development of breast cancer. Parity-induced protection can be reproduced in a carcinogen-induced rat mammary carcinoma model. The molecular mechanisms of parity-induced protection against carcinogenic stimuli in rat mammary glands have not been fully characterized. In order to gain a better understanding of these molecular mechanisms, we performed gene expression analyses in parous and age-matched virgin (AMV) mammary glands of Lewis rats before and after carcinogen (N-methyl-N-nitrosourea; MNU) treatment.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Norihisa Uehara 

PROVIDER: E-GEOD-2726 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Parous mammary glands exhibit distinct alterations in gene expression and proliferation responsiveness to carcinogenic stimuli in Lewis rats.

Uehara Norihisa N   Unami Akira A   Kiyozuka Yasuhiko Y   Shikata Nobuaki N   Oishi Yuji Y   Tsubura Airo A  

Oncology reports 20060401 4


Early full-term pregnancy affords lifetime protection against the development of breast cancer. Parity-induced protection can be reproduced in a carcinogen-induced rat mammary carcinoma model, but the molecular mechanisms of this protection against carcinogenic stimuli in rat mammary glands have not been fully characterized. To gain a better understanding of these molecular mechanisms, we used an oligonucleotide microarray to examine gene expression in parous and age-matched virgin (AMV) mammary  ...[more]

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