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Transcriptional response of an azole-resistant Candida parapsilosis isolate [fluconazole].

ABSTRACT: Azole resistance was induced in vitro by growth of a susceptible C. parapsilosis isolate in the presence of fluconazole. Whole genome microarrays were used to compare the transcriptional response of the fluconazole-resistant and susceptible isolates. Transcriptional profile of in vitro derived fluconazole resistant isolate of C. parapsilosis (BC014FLC) compared to susceptible isolate (BC014S). Cell were grown in YPD medium in normoxia at 35 degrees. Each strain was labelled with Cy3 or Cy5. Overall, 4 independent biological replicates were compared; 2 dye swaps were performed to normalize dye effects.

ORGANISM(S): Candida parapsilosis

SUBMITTER: Geraldine Butler

PROVIDER: E-GEOD-27405 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Transcriptional response of an azole-resistant Candida parapsilosis isolate.

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