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Deficiency of CXCR2, but Not Other Chemokine Receptors, Attenuates Autoantibody-Mediated Arthritis in a Murine Model

ABSTRACT: To examine patterns of gene expression in ankle synovial fluid cells and peripheral blood leukocytes during serum transferred arthritis. A time-course microarray analysis of serum-transferred arthritis was performed, examining ankle tissue, synovial fluid, and peripheral blood leukocytes.

ORGANISM(S): Mus musculus

SUBMITTER: CBDM Lab 

PROVIDER: E-GEOD-27492 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Deficiency of CXCR2, but not other chemokine receptors, attenuates autoantibody-mediated arthritis in a murine model.

Jacobs Jonathan P JP   Ortiz-Lopez Adriana A   Campbell James J JJ   Gerard Craig J CJ   Mathis Diane D   Benoist Christophe C  

Arthritis and rheumatism 20100701 7

<h4>Objective</h4>Chemokines coordinate leukocyte trafficking in homeostasis and during immune responses. Prior studies of their role in arthritis have used animal models with both an initial adaptive immune response and an inflammatory effector phase. We undertook analysis of chemokines and their receptors in the effector phase of arthritis using the K/BxN mouse serum-transfer model.<h4>Methods</h4>A time-course microarray analysis of serum-transferred arthritis was performed, examining ankle t  ...[more]

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