Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Lea Gregersen
PROVIDER: E-GEOD-27529 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Leucci E E Zriwil A A Gregersen L H LH Jensen K T KT Obad S S Bellan C C Leoncini L L Kauppinen S S Lund A H AH
Oncogene 20120206 49
MicroRNAs are important regulators of gene expression in normal development and disease. miR-9 is overexpressed in several cancer forms, including brain tumours, hepatocellular carcinomas, breast cancer and Hodgkin lymphoma (HL). Here we demonstrated a relevance for miR-9 in HL pathogenesis and identified two new targets Dicer1 and HuR. HL is characterized by a massive infiltration of immune cells and fibroblasts in the tumour, whereas malignant cells represent only 1% of the tumour mass. These ...[more]