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Potential Prognostic Biomarkers for Bone Metastasis from Hepatocellular Carcinoma

ABSTRACT: RNA was extracted from 48 pairs of intratumoral and peritumoral formalin-fixed, paraffin-embedded (FFPE) tissue from hepatocellular carcinoma (HCC) patients with and without bone metastases (BM). The Human Cancer Panel DASL Assay containing 502 cancer-related genes was used to identify novel BM-associated genes. A cDNA-mediated annealing, selection, extension, and ligation assay was performed with an array of 502 known cancer-related genes to identify differentially expressed genes in 96 RNA samples. Total RNA was purified from the tissue specimens using the High Pure RNA Paraffin Kit according to the manufacturer’s protocol. DASL experiments were performed to identify genes that were differentially expressed between the BM and NBM groups of matched intratumoral and peritumoral tissues by using A cDNA-mediated annealing, selection, extension, and ligation assay.

ORGANISM(S): Homo sapiens

SUBMITTER: Zuolin Xiang 

PROVIDER: E-GEOD-27635 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Potential prognostic biomarkers for bone metastasis from hepatocellular carcinoma.

Xiang Zuo-Lin ZL   Zeng Zhao-Chong ZC   Tang Zhao-You ZY   Fan Jia J   He Jian J   Zeng Hai-Ying HY   Zhu Xiao-Dong XD  

The oncologist 20110610 7

<h4>Background</h4>Hepatocellular carcinoma (HCC) most commonly develops in patients who have a viral infection, especially in the case of hepatitis B virus (HBV), and in patients with a chronic liver disease. HCC patients with bone metastasis (BM) suffer from pain and other symptoms that significantly reduce their quality of life. Identification of patients who are at high risk for BM after undergoing potentially curative treatment for HCC remains challenging. Here, we aimed to identify HCC BM-  ...[more]

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