Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Gudmundur Norddahl
PROVIDER: E-GEOD-27686 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Norddahl Gudmundur L GL Pronk Cornelis J CJ Wahlestedt Martin M Sten Gerd G Nygren Jens M JM Ugale Amol A Sigvardsson Mikael M Bryder David D
Cell stem cell 20110501 5
Somatic stem cells mediate tissue maintenance for the lifetime of an organism. Despite the well-established longevity that is a prerequisite for such function, accumulating data argue for compromised stem cell function with age. Identifying the mechanisms underlying age-dependent stem cell dysfunction is therefore key to understanding the aging process. Here, using a model carrying a proofreading-defective mitochondrial DNA polymerase, we demonstrate hematopoietic defects reminiscent of prematur ...[more]