Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression profiles of Barrett's esophagus, squamous esophagus and gastric cardia


ABSTRACT: SAGE performed on biopsies of Barrett's esophagus, squamous esophagus and gastric cardia taken from a metaplastic Barrett's esophagus patient. Keywords: SAGE comparative analysis of gene expression profiles of Barrett's esophagus, normal squamous esophagus and gastric cardia tissue

ORGANISM(S): Homo sapiens

SUBMITTER: Jantine van Baal 

PROVIDER: E-GEOD-2769 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A comparative analysis by SAGE of gene expression profiles of Barrett's esophagus, normal squamous esophagus, and gastric cardia.

van Baal Jantine W P M JW   Milano Francesca F   Rygiel Agnieszka M AM   Bergman Jacques J G H M JJ   Rosmolen Wilda D WD   van Deventer Sander J H SJ   Wang Kenneth K KK   Peppelenbosch Maikel P MP   Krishnadath Kausilia K KK  

Gastroenterology 20051001 4


<h4>Background & aims</h4>The metaplastic process in which the normal squamous epithelium of the distal esophagus is replaced by columnar-lined epithelium, known as Barrett's esophagus (BE), is poorly understood. The aim of this study was to define, analyze, and compare transcription profiles of BE, normal cardia epithelium, and squamous epithelium to gain more insight into the process of metaplasia and to identify uniquely expressed genes in these epithelia.<h4>Methods</h4>Serial analysis of ge  ...[more]

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