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Gene expression profiles of spontaneous gastric tumors in the antrum of the stomach of 30,60, and 90 day old CEA424-SV40 -T antigen transgenic mice.

ABSTRACT: Analysis of global gene expression in the antral portion of the stomach in control and mice with a developing tumor to get further insight into the exact tumor type and the influence of local gene expression. Total RNA obtained from tissue samples from the antrum. Follow up of gene expression over the time of the tumor development

ORGANISM(S): Mus musculus

SUBMITTER: Joachim Schultze

PROVIDER: E-GEOD-27711 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Expression of a neuroendocrine gene signature in gastric tumor cells from CEA 424-SV40 large T antigen-transgenic mice depends on SV40 large T antigen.

Ihler Fritz F Vetter Elena Viviana EV Pan Jie J Kammerer Robert R Debey-Pascher Svenja S Schultze Joachim L JL Zimmermann Wolfgang W Enders Georg G

PloS one 20120113 1

<h4>Background</h4>A large fraction of murine tumors induced by transgenic expression of SV40 large T antigen (SV40 TAg) exhibits a neuroendocrine phenotype. It is unclear whether SV40 TAg induces the neuroendocrine phenotype by preferential transformation of progenitor cells committed to the neuroendocrine lineage or by transcriptional activation of neuroendocrine genes.<h4>Methodology/principal findings</h4>To address this question we analyzed CEA424-SV40 TAg-transgenic mice that develop spont ...[more]

PMID: 22253802

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GC424 tumor cells and gastric tumors

Project description:This SuperSeries is composed of the following subset Series: GSE27710: Gene expression profiles of control GC424 tumor cell lines and after downregulation of the SV40 large T-antigen GSE27711: Gene expression profiles of spontaneous gastric tumors in the antrum of the stomach of 30,60, and 90 day old CEA424-SV40 -T antigen transgenic mice. Refer to individual Series

2012-08-01 | E-GEOD-27712 | biostudies-arrayexpress

Gene expression profiles of spontaneous gastric tumors in the antrum of the stomach of 30,60, and 90 day old CEA424-SV40 -T antigen transgenic mice.

Project description:Analysis of global gene expression in the antral portion of the stomach in control and mice with a developing tumor to get further insight into the exact tumor type and the influence of local gene expression.

2012-08-02 | GSE27711 | GEO

Gene expression profiles of control GC424 tumor cell lines and after downregulation of the SV40 large T-antigen

Project description:Analysis of global gene expression in a tumor cell line established from a CEA424-Tag mouse and comparison with the expressed gene profile after downregulating the expression of the large T antigen Total RNA obtained from cultured control cell lines and after siRNA mediated downregulation of the SV40 large T antigen

2012-08-01 | E-GEOD-27710 | biostudies-arrayexpress

microRNA profiling in duodenal ulcer disease caused by Helicobacter pylori infection in a Western population.

Project description:The aim of this study was to identify and assess the utility of miRNAs as diagnostic surrogate markers for H.pylori infection. For this purpose, we analyzed the miRNA expression profile by microarrays in the antral mucosa of well characterized dyspeptic patients and then applied the most significant set of miRNAs to an independent validation group. Our results shows that a set of miRNAs are deregulated during chronic gastric inflammation and that this set may be may be useful as a surrogate marker for determining the presence of H.pylori. Total RNA from antral biopsies from patients with Helicobacter pylory (Hp) infection (with or without virulence factor caG) and healthy volunteers were isolated. MiRNA expression profiles were analyzed using miRNA microarray platform.

2012-09-01 | E-GEOD-32174 | biostudies-arrayexpress

Cross-species single-cell transcriptomic analysis reveals the landscape of animal gastric antrum [scRNA-Seq]

Project description:Purpose: To reveal the consistency and difference of gastric antrum epithelial cells among species and provides insights into the selection of model organisms in different research directions in the future. Methods:In this study, we collected antrum epithelial tissues from human, pig, rat and mouse for scRNA-seq and conducted cross species analysis. Results: In pig antral epithelium, we identify a novel cell cluster. We also discovered that the porcine antral epithelium owns stronger immune function than the other species. Further analysis reveals this may be due to the insufficient function of porcine immune cells. Conclusions:Our results replenish the information of multiple species of gastric antral epithelium at the single cell level, providing data resources for understanding the basic situation of gastric antrum epithelial cells.

2023-09-11 | GSE225275 | GEO

Severe induction of aberrant DNA methylation by nodular gastritis in adults

Project description:Background: Nodular gastritis (NG) is characterized by marked antral lymphoid follicle formation, and is a strong risk factor for diffuse-type gastric cancer in adults. However, it is unknown whether aberrant DNA methylation, which is induced by atrophic gastritis (AG) and is a risk for gastric cancer, is induced by NG. Here, we analyzed methylation induction by NG. Methods: Gastric mucosal samples were obtained from non-cancerous antral tissues of 16 NG and 20 AG patients with gastric cancer and 5 NG and 6 AG patients without, all age- and gender-matched. Genome-wide methylation analysis and expression analysis were conducted by a BeadChip array and RNA-sequencing, respectively. Results: Clustering analysis of non-cancerous antral tissues of NG and AG patients with gastric cancer was conducted using methylation levels of 585 promoter CpG islands (CGIs) of methylation-resistant genes, and a large fraction of NG samples formed a cluster with strong methylation induction. Promoter CGIs of CDH1 and DAPK1 tumor-suppressor genes were more methylated in NG than in AG. Notably, methylation levels of these genes were also higher in the antrum of NG patients without cancer. Genes related to lymphoid follicle formation, such as CXCL13/CXCR5 and CXCL12/CXCR4, had higher expression in NG, and genes involved in DNA demethylation TET2 and IDH1, had only half the expression in NG. Conclusions: Severe aberrant methylation, involving multiple tumor-suppressor genes, was induced in the gastric antrum and body of patients with NG, in accordance with their high gastric cancer risk.

2024-08-27 | GSE211463 | GEO

Transcriptome analyses of ovarian stroma: tunica albuginea, interstitium and theca interna

Project description:The ovary has specialized stromal compartments, including the tunica albuginea, interstitial stroma and theca interna, which develops concurrently with the follicular antrum. To characterize the molecular determinants of these compartments, stroma adjacent to preantral follicles (pre-theca), interstitium and tunica albuginea were laser microdissected (n = 4 per group) and theca interna was dissected from bovine antral follicles (n = 6).

2019-09-17 | GSE137471 | GEO

Stromal cells from the murine stomach antrum - single cell RNA seq

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Proteome of fluid from human small antral follicles reveals insights in folliculogenesis and oocyte maturation.

Project description:Human ovarian follicles develop a fluid-filled antrum when they reach a diameter of around 250 µm. The antrum contains follicular fluid (FF) composed of secretions from cells in the follicle and from circulation. The composition of FF undergoes massive changes in relation to follicular development. Previously, only FF from large pre-ovulatory follicles aspirated just prior to ovulation, has been analyzed by proteomics; resulting in a high proportion of plasma proteins being detected due to diffusion of proteins through the increasingly leaky basal membrane in larger follicles. We present the first proteomics analysis of FF from normal unstimulated human small antral ovarian follicles (diameter: 3-8mm) identifying the largest number of proteins reported in human FF to date: 2,050 proteins of which 1,151 were identified for the first time in human FF by mass spectrometry. Furthermore, an identified growth factor, midkine, was shown to impact follicular regulatory processes including enhancement of nuclear maturation of immature human oocytes.

2021-09-08 | PXD013344 | Pride

Human Breast Tumor Cored Sample mRNA Array

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