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Transcription profiling of Drosophila melanogaster yw, w118 and p53 mutant embryoes irradiated with gamma rays reveals p53 directs focussed genomic responses in Drosophila


ABSTRACT: Embryos were collected, aged, mock-treated/treated with 40Gy gamma radiation, and allowed to recover for 1.5 hours. Targets from 3 sets of wild type (yw, w1118) and 2 sets of mutant (Dmp53NS) biological replicates were generated and the expression profiles were determined using Affymetrix Drosophila Genechip 1 arrays. Comparisons between the sample groups allow the identification of genes with radiation-responsive and Dmp53-dependent expression patterns. Experiment Overall Design: 3 sets of paired control and irradiated Wild Type and 2 sets of paired control and irradiated Mutant (Dmp53NS) biological replicates were analyzed

ORGANISM(S): Drosophila melanogaster

SUBMITTER: John Abrams 

PROVIDER: E-GEOD-2780 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

p53 directs focused genomic responses in Drosophila.

Akdemir F F   Christich A A   Sogame N N   Chapo J J   Abrams J M JM  

Oncogene 20070219 36


p53 is a fundamental determinant of cancer susceptibility and other age-related pathologies. Similar to mammalian counterparts, Drosophila p53 integrates stress signals and elicits apoptotic responses that maintain genomic stability. To illuminate core-adaptive functions controlled by this gene family, we examined the Drosophila p53 regulatory network at a genomic scale. In development, the absence of p53 impacted constitutive expression for a surprisingly broad scope of genes. By contrast, stim  ...[more]

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