Dataset Information
Intragenic enhancers act as alternative promoters
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Monika Kowalczyk
PROVIDER: E-GEOD-27921 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Intragenic enhancers act as alternative promoters.
Molecular cell 20120119 4
A substantial amount of organismal complexity is thought to be encoded by enhancers which specify the location, timing, and levels of gene expression. In mammals there are more enhancers than promoters which are distributed both between and within genes. Here we show that activated, intragenic enhancers frequently act as alternative tissue-specific promoters producing a class of abundant, spliced, multiexonic poly(A)(+) RNAs (meRNAs) which reflect the host gene's structure. meRNAs make a substan ...[more]
